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HLA-B*07 is a high risk allele for familial cervical cancer
Xiaoping Qiu1, Fan Zhang, Dangxiao Chen
1Institute of Virology, Medical School of Wuhan University, Wuhan, China. xpingqiu429@gmail.com
Aim:
The purpose of this study was to investigate 50 women from eight families with familial cervical cancer in Wufeng County, Hubei Province, China, a region with a high incidence of cervical cancer. Eighty-nine healthy women, of similar age, location and ethnicity, were selected as a control group.
Methods:
Blood samples were collected from both groups, and HLA-A, HLA-B, and HLA-DRB1 genotypes were profiled with the Multi-Analyte Profiling system (xMAP) (Luminex HLA-SSO) using a WAKFlow HLA typing kit. Results were analyzed with Luminex HLA typing software and showed good stability, reproducibility and specificity.
Results:
We found several high risk alleles in women with familial cervical cancer, that associated with the highest risk being HLA-B*07 (OR = 8.7, 95% CI = 1.8-41.1).
Conclusions:
HLA-B*07 is a high risk allele for cervical cancer, and has strong potential for use as a molecular biomarker.
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