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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

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Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
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Tumor microenvironment: a main actor in the metastasis process.

Daniela Spano1, Massimo Zollo

  • 1Biotecnologie Avanzate, Centro di Ingegneria Genetica, Via Gaetano Salvatore 486, 80145 Naples, Italy.

Clinical & Experimental Metastasis
|February 11, 2012
PubMed
Summary

The tumor microenvironment, influenced by cancer cells and host factors, is crucial for metastasis. Understanding these interactions is key to developing new cancer therapies.

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Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Published on: June 13, 2016

Area of Science:

  • Oncology
  • Cancer Biology
  • Tumor Microenvironment

Background:

  • Metastasis is influenced by both cancer cell intrinsic properties and extrinsic host microenvironment factors.
  • The tumor microenvironment (TME) plays a critical role in supporting cancer progression through molecular signaling.
  • Interactions within the TME are complex and essential for metastasis formation.

Purpose of the Study:

  • To summarize the current understanding of the cells and interactions within the metastatic niche.
  • To highlight the role of the TME in promoting metastasis.
  • To emphasize the importance of TME research for developing novel cancer therapeutics.

Main Methods:

  • Review of existing literature on tumor microenvironment and metastasis.
  • Synthesis of current knowledge on cellular players and their interactions in the metastatic niche.
  • Analysis of the 'state of the art' in TME research.

Main Results:

  • Identified key cellular components and their functions in establishing the metastatic niche.
  • Detailed the network of interactions between cancer cells and the host microenvironment.
  • Highlighted the modulatory effects of secreted molecules on cancer cell phenotype.

Conclusions:

  • The tumor microenvironment is a critical determinant of metastasis, involving complex cellular interactions.
  • Understanding these interactions is vital for targeting cancer initiation and recurrence.
  • Further research into the TME holds promise for developing effective anti-cancer therapies.