Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Regression Toward the Mean01:52

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...
Probability Laws01:49

Probability Laws

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Co-culturing hiPSC-cardiomyocytes and cardiac fibroblasts enhances engineered heart tissue structure and function.

Stem cells translational medicine·2026
Same author

Towards a neurophysiological model of kundalini: a theoretical framework informed by preliminary clinical observations.

Frontiers in behavioral neuroscience·2026
Same author

VarStack2-an interactive web tool for somatic variant interpretation in cancer.

Database : the journal of biological databases and curation·2026
Same author

Design and Synthesis of a High-Performance Copper(II) Metal-Organic Framework Featuring Large Surface Area and Enhanced Methane Adsorption Capacity from a Thiophene-Functionalized Diisophthalic Acid Ligand.

Inorganic chemistry·2026
Same author

Hypomorphic Protein Expression of DNA Polymerase Beta in Polβ<sup>L301R-V303R/L301R-V303R</sup> Knock-In Transgenic Mice Does Not Impact Global DNA Methylation Levels in the Midbrain.

Biomolecules·2026
Same author

Revised Two-Stage Model of Preeclampsia Based on Autophagic Dysfunction: A Comprehensive Review.

Biomolecules·2026
Same journal

Development of CypriSSR: a genome-wide, chromosome-level microsatellite database for multiple cyprinidae species.

Database : the journal of biological databases and curation·2026
Same journal

KitBase Expanded: An Integrated Genomic and Phenotypic Resource for 3,268 Fast-Neutron-Irradiated Rice Mutants.

Database : the journal of biological databases and curation·2026
Same journal

PhaLP 2.0: extending the community-oriented phage lysin database with a SUBLYME pipeline for metagenomic discovery.

Database : the journal of biological databases and curation·2026
Same journal

A similarity metric, rubric, and unified hierarchy for biomedical publication types and study designs.

Database : the journal of biological databases and curation·2026
Same journal

GUTAID: a curated database linking gut microbial antigens to autoimmune mechanisms.

Database : the journal of biological databases and curation·2026
Same journal

Rosetta Statements: simplifying FAIR knowledge graph construction with a user-centred approach.

Database : the journal of biological databases and curation·2026
See all related articles

Related Experiment Video

Updated: May 25, 2026

Preterm EEG: A Multimodal Neurophysiological Protocol
19:32

Preterm EEG: A Multimodal Neurophysiological Protocol

Published on: February 18, 2012

dbPTB: a database for preterm birth.

Alper Uzun1, Alyse Laliberte, Jeremy Parker

  • 1Department of Pediatrics, Women & Infants Hospital of Rhode Island, Providence, RI 02905, USA.

Database : the Journal of Biological Databases and Curation
|February 11, 2012
PubMed
Summary
This summary is machine-generated.

This study introduces a novel bioinformatics approach to identify genetic variants linked to complex diseases like preterm birth. A web-based tool aggregates genetic data and pathways, creating a valuable resource for researchers.

More Related Videos

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
09:00

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients

Published on: April 13, 2021

Related Experiment Videos

Last Updated: May 25, 2026

Preterm EEG: A Multimodal Neurophysiological Protocol
19:32

Preterm EEG: A Multimodal Neurophysiological Protocol

Published on: February 18, 2012

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
09:00

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients

Published on: April 13, 2021

Area of Science:

  • Genetics
  • Bioinformatics
  • Computational Biology

Background:

  • Genome-wide association studies (GWAS) are popular for complex disease research but face challenges in identifying genetic variants.
  • Identifying genetic variants for complex diseases remains a significant hurdle in human genetics.

Purpose of the Study:

  • To develop and test a novel bioinformatics approach for identifying nominal genetic variants associated with complex diseases.
  • To create a web-based aggregation tool for organizing genes, genetic variations, and pathways related to preterm birth.

Main Methods:

  • Utilized semantic data mining to extract and curate published articles on preterm birth.
  • Aggregated genes from public databases, expression arrays, and literature curation.
  • Employed pathway analysis to impute additional relevant genes.

Main Results:

  • Developed a novel bioinformatics approach for identifying genetic variants in complex diseases.
  • Created a web-based aggregation tool organizing preterm birth-related genetic information.
  • Established a unique resource combining curated literature and genetic data for preterm birth research.

Conclusions:

  • The developed bioinformatics approach is effective for identifying genetic variants associated with complex diseases.
  • The created database for preterm birth is a valuable resource for researchers.
  • This approach is generalizable to other complex disorders with genetic contributions.