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Updated: May 25, 2026
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CometChip: A High-throughput 96-Well Platform for Measuring DNA Damage in Microarrayed Human Cells
Published on: October 18, 2014
Padlock probes and rolling circle amplification for detection of repeats and single-copy genes in the single-cell
Sara Henriksson1, Mats Nilsson
1Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Methods in Molecular Biology (Clifton, N.J.)
|February 11, 2012
Abstract:
Padlock probes and rolling circle amplification are techniques which can be used for detection of DNA sequences in situ with high specificity and high signal to noise. The single-cell gel electrophoresis assay is used to measure DNA damage and repair in cells. Here, we describe how padlock probes and rolling circle amplification can be used to detect DNA sequences within comet preparations.
