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Exercise training blunts oxidative stress in sickle cell trait carriers
Erica N Chirico1, Cyril Martin, Camille Faës
1Center of Research and Innovation on Sports, University Claude Bernard Lyon 1, University of Lyon, Villeurbanne, France.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|February 11, 2012
Summary
Exercise training improves oxidative stress and nitric oxide response in sickle cell trait carriers. Regular physical activity may help manage oxidative stress, potentially benefiting vascular health in individuals with hemoglobin S carriers.
Area of Science:
- Exercise Physiology
- Biochemistry
- Hematology
Background:
- Sickle cell trait (SCT) carriers may experience increased oxidative stress, potentially contributing to endothelial dysfunction and vascular impairment.
- The impact of exercise training on oxidative stress markers in SCT carriers requires further investigation.
Purpose of the Study:
- To analyze the effects of exercise training on oxidative stress and antioxidant markers in sickle cell trait carriers.
- To compare oxidative stress and nitric oxide responses to maximal exercise between trained and untrained SCT carriers and controls.
Main Methods:
- Assessed plasma levels of oxidative stress markers (AOPP, protein carbonyl, MDA, nitrotyrosine) and antioxidant markers (catalase, GPX, SOD), and NOx.
- Measured markers at baseline, immediately post-exercise (T(ex)), and during recovery (T(1h), T(2h), T(24h)).
- Compared trained (≥8 h/wk) and untrained subjects with sickle cell trait (SCT) and control (CON) status.
Main Results:
- Trained subjects exhibited higher superoxide dismutase (SOD) activity and lower advanced oxidation protein products (AOPP) and protein carbonyl levels compared to untrained subjects post-exercise.
- Untrained SCT carriers showed significantly higher AOPP, nitrotyrosine, and protein carbonyl levels post-exercise compared to trained SCT carriers.
- Trained SCT carriers demonstrated higher SOD activity and nitric oxide metabolites (NOx) post-exercise compared to untrained SCT carriers.
Conclusions:
- Exercise training appears to improve the overall oxidative stress and nitric oxide response to exercise in sickle cell trait carriers.
- Physical activity may be a beneficial strategy for managing oxidative stress in SCT carriers.
- These findings suggest potential benefits for vascular health in hemoglobin S carriers through regular exercise.
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