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Related Experiment Video

Updated: May 25, 2026

Detection of Viruses from Bioaerosols Using Anion Exchange Resin

Detection of Viruses from Bioaerosols Using Anion Exchange Resin

Published on: August 22, 2018

Capturing a virus while it catches its breath.

Theodore C Pierson¹, Richard J Kuhn

¹Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, MD 20892, USA. piersontc@mail.nih.gov

Structure (London, England : 1993)

|February 14, 2012

Summary

This summary is machine-generated.

Developing effective dengue virus vaccines is challenging due to four distinct serotypes. A study reveals the structural basis of a cross-reactive antibody, offering new insights into dengue immunity and disease.

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Area of Science:

Virology
Immunology
Structural Biology

Background:

The four dengue virus serotypes pose a significant hurdle for vaccine development.
Understanding immune responses is crucial for combating dengue pathogenesis.

Purpose of the Study:

To elucidate the structural basis of a cross-reactive neutralizing antibody against dengue virus.
To gain deeper insights into immune protection and disease mechanisms.

Main Methods:

Structural analysis of a cross-reactive neutralizing antibody.
Investigation of antibody-antigen interactions.

Main Results:

Detailed structural characterization of a broadly protective antibody.
Identification of key structural features enabling cross-serotype neutralization.

Conclusions:

The findings provide a structural foundation for designing broadly protective dengue vaccines.
This research enhances understanding of dengue virus immunology and potential therapeutic strategies.