[Neurologic disorders in insulinoma]

Area of Science:

• Neurology
• Endocrinology
• Oncology

Background:

• Insulinoma, a rare pancreatic neuroendocrine tumor, can cause hypoglycemia.
• Hypoglycemia-induced neurological symptoms are often complex and varied.
• Understanding these neuropsychic disturbances is crucial for timely diagnosis and management.

Observation:

• Three cases of insulinoma with significant neuropsychic disturbances are presented.
• Epileptiform syndromes, dysphoric episodes, and lethargy were commonly observed.
• A rare case of coma vigil in advanced insulinoma is detailed.

Findings:

• The study highlights the polymorphic nature of insulinoma-related neurological symptoms.
• Pathogenetic mechanisms involve severe hypoglycemia affecting brain function.
• Differential diagnosis is challenging due to the wide spectrum of presentations.

Implications:

• Early recognition of neuropsychic symptoms is vital for diagnosing insulinoma.
• This emphasizes the need for a multidisciplinary approach in managing complex cases.
• Further research into the neurobiological impact of insulinoma is warranted.