Rh-catalyzed intramolecular sp2 C-H bond difluoromethylenation
Yajun Li1, Jiangtao Zhu, Haibo Xie
1Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Abstract:
A new Rh-catalyzed intramolecular coupling reaction of a CF(2)Br group with a 2-aryl of indole or pyrrole via C-H bond activation is presented. This reaction represents a new way of incorporating difluoromethylene groups into organic compounds. Preliminary mechanistic studies suggest that this reaction might not occur via a conventional free radical pathway.
More Related Videos
Related Concept Videos
Electrophilic 1,2- and 1,4-Addition of X2 to 1,3-Butadiene
Halogenation of Alkenes
Consider the bromination of cyclopentene. Molecular bromine is polarized in the proximity of the π electrons of cyclopentene. An electrophilic bromine atom adds across the double bond, forming a cyclic bromonium ion intermediate.
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Electrophilic 1,2- and 1,4-Addition of HX to 1,3-Butadiene
Electrophilic Addition to Alkynes: Hydrohalogenation
Radical Reactivity: Intramolecular vs Intermolecular


