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Solubility03:00

Solubility

Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules, atoms, and/or ions)...
Solvating Effects02:12

Solvating Effects

An understanding of the solvating effect helps rationalize the relation between solvation and acidity of the compound. In addition, this also explains the relative stability of conjugate bases for compounds with different pKa values. This lesson details, in-depth, the principle of solvating effects. The strength of an acid and the stability of its corresponding conjugate base are determined using pKa values. This observed relationship is a consequence of solvation, which is the interaction...
Solubility Equilibria: Overview01:09

Solubility Equilibria: Overview

When a substance such as sodium chloride is added to water, it dissolves, forming an aqueous solution. The extent of dissolution is called solubility. The process of dissolution can exist in equilibrium, just like other chemical processes. Solubility equilibria are also called precipitation equilibria because the process of solubility can be reversible. The reverse of the solubility process is called precipitation.
Solubility is important in biological and environmental processes. A notable...
Solubility Equilibria03:07

Solubility Equilibria

Solubility equilibria are established when the dissolution and precipitation of a solute species occur at equal rates. These equilibria underlie many natural and technological processes, ranging from tooth decay to water purification. An understanding of the factors affecting compound solubility is, therefore, essential to the effective management of these processes. This section applies previously introduced equilibrium concepts and tools to systems involving dissolution and precipitation.
The...
Liquid–Solid Solutions01:29

Liquid–Solid Solutions

The process of a solid dissolving in a liquid to form a solution is governed by the solubility limit, which is the maximum amount of the solid substance, or solute, that can be dissolved in a specific volume of the liquid or solvent. As the solute dissolves, it reaches a point where no more solute can be dissolved at a given temperature - this is known as the saturation point. However, if further solute is added and it manages to dissolve, the solution becomes supersaturated. Supersaturated...
Physical Properties Affecting Solubility02:19

Physical Properties Affecting Solubility

Solutions of Gases in Liquids
As for any solution, the solubility of a gas in a liquid is affected by the attractive intermolecular forces between solute and solvent species. Unlike solid and liquid solutes, however, there is no solute-solute intermolecular attraction to overcome when a gaseous solute dissolves in a liquid solvent since the atoms or molecules comprising a gas are far separated and experience negligible interactions. Consequently, solute-solvent interactions are the sole...

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Related Experiment Video

Updated: May 25, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

Redefining solubility parameters: the partial solvation parameters.

Costas Panayiotou1

  • 1Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece. cpanayio@auth.gr

Physical Chemistry Chemical Physics : PCCP
|February 14, 2012
PubMed
Summary
This summary is machine-generated.

This study introduces a new, four-part solubility parameter based on quantum chemistry, enhancing predictions for chemical compound solubility. This advanced approach improves upon traditional methods for pharmaceuticals and polymers.

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Last Updated: May 25, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
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Area of Science:

  • Physical Chemistry
  • Quantum Chemistry
  • Materials Science

Background:

  • The classical solubility parameter is a fundamental concept in physical chemistry.
  • Existing models have inherent restrictions and limited applications.
  • Modern quantum chemical calculations offer new insights into molecular interactions.

Purpose of the Study:

  • To propose a new definition of the solubility parameter.
  • To overcome limitations of the original definition and expand its applicability.
  • To develop a more comprehensive understanding of chemical compound interactions.

Main Methods:

  • Reconsidering the classical solubility parameter using quantum chemical calculations.
  • Replacing the single parameter with four partial solvation parameters: dispersion, polar, acidic, and basic.
  • Utilizing COSMO-RS theory and the concept of complementarity matching for acidic/basic components.
  • Comparing results with Abraham's acid/base descriptors.

Main Results:

  • A new, four-component solubility parameter (dispersion, polar, acidic, basic) has been defined and calculated.
  • The new parameter incorporates both similarity and complementarity matching principles.
  • The method shows accurate predictions for solubility data of pharmaceuticals and polymers.
  • Quantum mechanics-based results align well with Abraham's acid/base descriptors.

Conclusions:

  • The proposed four partial solvation parameters offer a more nuanced and applicable approach to solubility prediction.
  • This method expands the utility of solubility parameters in physical chemistry.
  • The integration of quantum mechanics and complementarity matching provides a robust predictive tool.