[Trials to obtain a hyperimmune serum against bovine mucosal disease-virus diarrhea]

Obtained are two types of hyperimmune sera against the virus of the mucous disease--viral diarrhea (MD--VD) by means of subcutaneous and venous hyperimmunization of cattle with a live viral suspension: (a) A polyvariant hyperimmune serum, obtained by the use of four local and reference strains of the MD--VD virus with a neutralization titre against the Nadl strain of 1 : 1280. (b) Monovariant hyperimmune serum, prepared by the use of a reference strain of the MD--VD virus with a neutralization titre against the Nadl strain of 1 : 1280. On testing experimental calves and application in practice, it has not been established that the polyvariant serum possesses a marked protective effect at a dose of 1 cm3/kg.