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The value of arterial spin-labeled perfusion imaging in acute ischemic stroke: comparison with dynamic susceptibility

Danny J J Wang1, Jeffry R Alger, Joe X Qiao

  • 1Department of Neurology, University of California Los Angeles, 660 Charles E. Young Drive South, Los Angeles, CA 90095, USA. jwang71@gmail.com

Stroke
|February 14, 2012
PubMed
Abstract

Insights

Arterial spin-labeled (ASL) perfusion MRI is a valuable, noninvasive tool for detecting blood flow abnormalities in acute ischemic stroke (AIS). It offers consistent results compared to dynamic susceptibility contrast (DSC) MRI and better highlights hyperemic lesions.

Area of Science:

  • Neuroimaging
  • Radiology
  • Medical Diagnostics

Background:

  • Acute ischemic stroke (AIS) requires prompt and accurate diagnosis.
  • Perfusion MRI techniques are crucial for assessing cerebral blood flow in AIS.
  • Comparing novel techniques with established methods is essential for clinical adoption.

Purpose of the Study:

  • To evaluate the clinical utility of arterial spin-labeled (ASL) perfusion MRI in AIS.
  • To compare ASL perfusion MRI with dynamic susceptibility contrast (DSC) perfusion MRI.
  • To assess the consistency and lesion conspicuity between ASL and DSC perfusion imaging.

Main Methods:

  • 26 patients with AIS underwent both pseudocontinuous ASL and DSC perfusion MRI.
  • Image quality and lesion severity were rated for both ASL and DSC maps.
  • Quantitative perfusion values were compared between ASL and DSC across vascular territories.

Main Results:

  • ASL and DSC perfusion maps showed consistent delineation of hypoperfused brain regions in AIS.
  • Hyperemic lesions were more conspicuous on ASL cerebral blood flow maps than on DSC maps.
  • ASL demonstrated comparable reliability to DSC in assessing perfusion deficits.

Conclusions:

  • Arterial spin-labeled (ASL) perfusion MRI is a rapid, noninvasive, and quantitative method for AIS.
  • ASL has significant clinical value in detecting blood flow abnormalities in AIS patients.
  • ASL offers advantages in visualizing certain perfusion abnormalities like hyperemia.

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