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Related Concept Videos

Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

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Related Experiment Video

Updated: May 25, 2026

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
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Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

Incremental enamel development in modern human deciduous anterior teeth.

Patrick Mahoney1

  • 1School of Anthropology and Conservation, University of Kent, Canterbury, UK. p.mahoney@kent.ac.uk

American Journal of Physical Anthropology
|February 15, 2012
PubMed
Summary

Human deciduous teeth show variations in enamel development, with mandibular incisors forming fastest and earliest. This developmental timing links to eruption sequences and aids infant age estimation.

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Last Updated: May 25, 2026

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Area of Science:

  • Paleoanthropology
  • Developmental Biology
  • Human Anatomy

Background:

  • Incremental enamel development provides insights into tooth formation timelines.
  • Understanding deciduous tooth development is crucial for estimating infant age-at-death.
  • Previous research has established patterns in permanent teeth and deciduous molars.

Purpose of the Study:

  • To reconstruct incremental enamel development in human deciduous anterior teeth.
  • To compare developmental differences along the tooth row and test specific hypotheses.
  • To explore links between enamel development and deciduous tooth eruption sequence.

Main Methods:

  • Reconstruction of incremental enamel development using Retzius lines and daily enamel secretion rates (DSRs).
  • Analysis of 42 deciduous mandibular and 42 maxillary anterior teeth (incisors and canines).
  • Comparison of results with previous studies on deciduous molars and permanent teeth.

Main Results:

  • Retzius line periodicity in anterior teeth ranged from 5–6 days; Intradian line periodicity was 12 hours.
  • Mean cuspal DSRs showed slight variations along the tooth row.
  • Mandibular incisors exhibited the earliest enamel initiation, fastest DSRs, and longest prenatal formation time, correlating with their early eruption.

Conclusions:

  • Developmental timing and rates vary along the deciduous tooth row, particularly in mandibular incisors.
  • These findings support links between enamel development, initiation times, and eruption sequences.
  • The reconstructed anterior crown formation times offer a valuable tool for estimating infant age-at-death.