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Trafficking of intracellular folates
Patrick J Stover1, Martha S Field
1Cornell University, Division of Nutritional Sciences, Ithaca, NY 14850, USA. pjs13@cornell.edu
Advances in Nutrition (Bethesda, Md.)
|February 15, 2012
Summary
Metabolic compartmentation organizes enzymes and controls pathway flux, but mechanisms remain unclear. This review explores folate metabolism, highlighting the need to regulate folate trafficking between pathways.
Area of Science:
- Biochemistry
- Metabolic Engineering
- Systems Biology
Background:
- Metabolic compartmentation spatially organizes enzymes, regulates pathway flux, and partitions intermediates.
- Understanding the mechanisms establishing metabolic architecture and inter-pathway communication is incomplete.
Purpose of the Study:
- To review advancements in understanding metabolic compartmentation within the folate-mediated one-carbon metabolic network.
- To present evidence for regulating folate trafficking among compartmentalized pathways.
Main Methods:
- Literature review of recent advancements in metabolic compartmentation research.
- Analysis of studies on the folate-mediated one-carbon metabolic network.
Main Results:
- Compartmentation plays a key role in organizing metabolic enzymes and regulating metabolic flux.
- Emerging evidence suggests a need to regulate folate trafficking within the one-carbon network.
Conclusions:
- Further research is needed to elucidate the mechanisms governing metabolic architecture and inter-network communication.
- Regulating folate trafficking is crucial for optimizing metabolic pathways.
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