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Related Experiment Video

Updated: May 24, 2026

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

A microbial association with autism.

Jorge L Benach¹, Ellen Li, Margaret M McGovern

¹Departments of Molecular Genetics and Microbiology, Medicine and Pediatrics, Stony Brook University, Stony Brook, New York, USA. jorge.benach@stonybrook.edu

|February 16, 2012

Summary

This summary is machine-generated.

Researchers found Sutterella bacteria in the ileal tissue of children with autism spectrum disorder (ASD) but not in controls. This suggests a potential role for Sutterella in ASD gastrointestinal issues.

Related Experiment Videos

Last Updated: May 24, 2026

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

Area of Science:

Microbiology
Neurodevelopmental Disorders
Gastroenterology

Background:

Autism spectrum disorder (ASD) is a complex developmental disability with frequent gastrointestinal (GI) comorbidities.
A consensus panel recommended further research into the prevalence and pathophysiology of GI disorders in ASD.
Previous studies have not fully elucidated the microbial contribution to GI issues in ASD.

Purpose of the Study:

To investigate the presence of specific bacterial species in the ileal mucosa of children with ASD and GI symptoms.
To determine if any bacterial species are uniquely associated with ASD in the ileal tissue.
To explore potential microbial etiologies or consequences of GI comorbidities in ASD.

Main Methods:

Analysis of ileal mucosal biopsy specimens from children diagnosed with ASD and control children with GI symptoms.
16S rRNA gene sequencing to identify bacterial composition.
Quantification of bacterial sequences, specifically Sutterella species.

Main Results:

Sutterella species were detected in the ileal mucosal biopsy specimens of children with ASD.
Sutterella was notably absent in control children presenting with GI symptoms.
Sutterella sequences constituted a significant proportion (1-7%) of the total bacterial load in ASD patients.

Conclusions:

The findings suggest a specific association between Sutterella species and the autism phenotype.
Sutterella may play a role in the pathophysiology of GI comorbidities observed in ASD.
This study opens new avenues for investigating the gut microbiome's impact on ASD.