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Serum uric Acid in smokers
Bassam E Hanna1, Jamal M Hamed, Luma M Touhala
1Department of Medicine, Nineveh college of medicine Biochemistry, Mosul, IRAQ.
Oman Medical Journal
|February 16, 2012
Summary
Smoking significantly lowers serum uric acid levels, potentially due to reduced production from oxidative stress. This finding suggests smokers should reduce or quit smoking and monitor uric acid as an indicator of antioxidant status.
Area of Science:
- Biochemistry
- Environmental Health
Background:
- Smoking is a major public health concern.
- Uric acid plays a role in oxidative stress and cardiovascular disease (CVD).
- The relationship between smoking and serum uric acid levels requires further elucidation.
Purpose of the Study:
- To investigate the effect of smoking on serum uric acid levels.
- To explore the correlation between smoking status and serum uric acid concentration.
Main Methods:
- A comparative study involving 120 male volunteers, divided into non-smokers and smokers.
- Measurement of serum and urine uric acid and creatinine levels.
- Statistical analysis to compare groups and assess correlations.
Main Results:
- Smokers exhibited significantly lower serum uric acid levels compared to non-smokers.
- No significant differences were observed in age, serum creatinine, or urinary uric acid excretion between groups.
- A negative correlation was found between smoking intensity (cigarettes/day, duration, cumulative) and serum uric acid.
Conclusions:
- Lower serum uric acid in smokers is attributed to reduced endogenous production caused by oxidative stress from cigarette smoke.
- The reduction in uric acid is dose-dependent on smoking status.
- Monitoring serum uric acid is recommended for smokers due to its association with CVD risk and its utility as a simple antioxidant indicator.
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