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[Chronic kidney disease what is it?].

Dominique Joly¹

¹Département de néphrologie-transplantation, hôpital Necker, 75743 Paris Cedex 15. doume.joly@gmail.com

La Revue Du Praticien

|February 17, 2012

Summary

Chronic kidney disease (CKD) means reduced kidney function or kidney damage lasting over three months. CKD increases the risk of end-stage renal disease and cardiovascular death.

Area of Science:

Nephrology
Internal Medicine
Cardiovascular Medicine

Context:

Chronic kidney disease (CKD) is characterized by a decreased glomerular filtration rate (GFR) below 60 mL/min/1.73 m2 or markers of kidney damage for at least three months.
CKD signifies an elevated risk for end-stage renal disease (ESRD) and cardiovascular mortality.
Current definitions may not fully capture patient prognosis.

Purpose:

To highlight the limitations of the current definition of chronic kidney disease.
To propose an improved definition incorporating age, GFR decline rate, and proteinuria.
To better stratify patient risk and differentiate physiological from pathological GFR reduction.

Summary:

The established definition of CKD involves reduced GFR or kidney damage markers for over three months.

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CKD is a significant risk factor for ESRD and cardiovascular mortality.

Future definitions should integrate patient age, GFR decline velocity, and proteinuria levels.

Impact:

Refining the CKD definition can lead to more accurate prognostication.
Improved patient stratification will aid in personalized treatment strategies.
This approach will help distinguish normal age-related GFR changes from pathological kidney disease.