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[Clinical characteristics of McCune-Albright syndrome in Chinese patients]
Jin Ma1, Chan Zhao, Guang-liang Shan
1Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Objective:
To present the ophthalmological characteristics of McCune-Albright syndrome (MAS).
Methods:
Case series study. Best corrected visual acuity (BCVA), visual field, color vision, retinal nerve fiber layer (RNFL) thickness, visual evoked potentials (VEP), fundus examination, computed tomography (CT) imaging of the optic canal, follow up results of multidisciplinary comprehensive treatments were analyzed.
Results:
Of the 6 patients, three were male and three were female. Their age were between 4 to 43 years old (median, 16 years old). Based on CT imaging of the optic canal, encasement of the optic canal was found in all 6 patients (12 eyes); three patients (6 eyes) had circumferential encasement of the optic canal; the remaining 3 patients (6 eyes) had partial encasement of the optic canal. Two patients (3 eyes) with circumferential encasement of the optic canal had optic neuropathy versus none in the remaining 9 eyes with circumferential or partial optic canal encasement. In addition, lengthening of the optic nerve was found in all 4 patients (8 eyes).
Conclusion:
Optic canal encasement and lengthening of the optic nerve are common in MAS patients, which is worthy of attention in clinical practice.