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Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

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Published on: December 4, 2020

Interventions for covert bacteriuria in children.

Anita Fitzgerald¹, Rintaro Mori, Monica Lakhanpaul

¹New Zealand Guidelines Group, Wellington, New Zealand. fitzgerald.anita@gmail.com

The Cochrane Database of Systematic Reviews

|February 17, 2012

Summary

This summary is machine-generated.

Treatment for covert bacteriuria in children shows short-term reduction in infection but lacks long-term benefits and data on harms. Antibiotic treatment for asymptomatic urinary tract infections in children may not be beneficial.

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Area of Science:

Pediatric Nephrology
Infectious Diseases
Evidence-Based Medicine

Background:

Covert bacteriuria in children has been studied since the 1970s, but treatment effectiveness remains uncertain due to mixed results.
Establishing the benefits and harms of antibiotic treatment is crucial for preventing kidney damage and infection recurrence.
Treatment decisions must weigh potential benefits against any harm to the child.

Purpose of the Study:

To evaluate the benefits and harms associated with treating covert bacteriuria in pediatric patients.
To synthesize evidence from randomized controlled trials on the efficacy of interventions for asymptomatic urinary tract infections in children.

Main Methods:

Searched CENTRAL, MEDLINE, and EMBASE for randomized and quasi-randomized controlled trials without language restrictions.
Included children up to 18 years with culture-proven urinary tract infection (UTI) and no urinary symptoms.
Assessed study quality and extracted data independently; used random-effects models for analysis.

Main Results:

Three randomized controlled trials (RCTs) involving 460 girls were included; studies had methodological limitations.
Antibiotic treatment showed a significant reduction in bacteriuria at six months but not at two years.
Long-term effectiveness (4-5 years) suggested a reduction in bacteriuria, with no observed differences in kidney growth; adverse effects were not reported.

Conclusions:

The current evidence base lacks sufficient detail on harms and benefits to draw reliable conclusions about treating covert bacteriuria.
Antibiotic treatment for covert bacteriuria in children is unlikely to provide long-term benefits.
Further high-quality research is needed to clarify the risks and benefits of treating this condition.