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Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: May 24, 2026

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
13:16

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

Autogenous bone graft: basic science and clinical implications.

Gary F Rogers1, Arin K Greene

  • 1Division of Plastic and Reconstructive Surgery, Children's National Medical Center, Washington, District of Columbia 22102, USA. grogers@cnmc.org

The Journal of Craniofacial Surgery
|February 17, 2012
PubMed
Summary
This summary is machine-generated.

Autogenous bone is the gold standard for craniomaxillofacial reconstruction due to osseointegration, but alternatives are needed. Surgeons must weigh biomaterial pros and cons for optimal patient outcomes.

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Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
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Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
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Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Published on: March 14, 2019

Area of Science:

  • Biomaterials Science
  • Craniomaxillofacial Surgery
  • Regenerative Medicine

Background:

  • No single biomaterial is ideal for all craniomaxillofacial (CMF) applications.
  • Autogenous bone is the current gold standard, offering vascularization and osseointegration.
  • Limitations of autogenous bone include donor site morbidity and availability issues.

Purpose of the Study:

  • To review the advantages and disadvantages of biomaterials for CMF applications.
  • To provide a framework for selecting the optimal biomaterial based on clinical situation.
  • To highlight the importance of understanding autogenous bone physiology.

Main Methods:

  • Literature review of biomaterials used in CMF surgery.
  • Analysis of clinical outcomes, cost, morbidity, and osseointegration potential.
  • Discussion of autogenous bone graft properties and limitations.

Main Results:

  • Autogenous bone offers superior osseointegration and reduced complication risk.
  • Alternative biomaterials are often expensive, lack osseointegration, and have unpredictable biologic activity.
  • Graft resorption, molding challenges, and limited availability impact autogenous bone use.

Conclusions:

  • Surgeons must select CMF biomaterials considering cost, morbidity, and success likelihood.
  • Understanding autogenous bone's physiologic behavior is crucial for optimal application.
  • Further research into biomaterials that mimic autogenous bone properties is warranted.