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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Updated: May 24, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

Immunity to TB and targets for immunotherapy.

Mercedes Gonzalez-Juarrero1

  • 1Department of Microbiology, Immunology & Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO 80523, USA. mercedes.gonzalez-juarrero@colostate.edu

Immunotherapy
|February 21, 2012
PubMed
Summary

Tuberculosis (TB) treatment faces challenges from drug-resistant strains. Immunotherapy offers a promising approach by enhancing the host immune response against Mycobacterium tuberculosis.

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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

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Last Updated: May 24, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Area of Science:

  • Immunology
  • Infectious Diseases
  • Global Health

Background:

  • Tuberculosis (TB) treatment has long been a global health challenge.
  • The emergence of multidrug-resistant Mycobacterium tuberculosis strains, coinciding with the AIDS epidemic, has worsened TB control prospects.
  • Existing therapies are becoming less effective, necessitating novel treatment strategies.

Purpose of the Study:

  • To review current understanding of TB immunity and identify immunotherapy targets.
  • To explore immunotherapy as a potential strategy to overcome drug resistance in TB treatment.
  • To discuss immunotherapy approaches that can be combined with current TB chemotherapy.

Main Methods:

  • Review of current literature on TB immunity and immunotherapy targets.
  • Analysis of various immunotherapy approaches, including antibody therapy, Th1 response enhancement, and modulation of inflammatory and immune pathways.
  • Examination of potential combination therapies with existing TB chemotherapy.

Main Results:

  • Immunotherapy holds potential to address drug resistance in TB by boosting the host's natural anti-TB immune response.
  • Several immunotherapy strategies are being explored, including anti-Mycobacteria antibodies, enhancing Th1 responses, and targeting immunosuppressive pathways.
  • These approaches aim to enhance the killing of Mycobacterium tuberculosis bacilli.

Conclusions:

  • Immunotherapy presents a vital avenue for developing new TB treatments, particularly against drug-resistant strains.
  • Combining immunotherapy with conventional chemotherapy may offer a more effective strategy for TB control.
  • Further research into TB immunity and immunotherapy targets is urgently needed to combat the growing threat of resistant TB.