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Related Concept Videos

Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
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Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Master Transcription Regulators02:23

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General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
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Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

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Related Experiment Video

Updated: May 24, 2026

Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry
14:47

Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry

Published on: May 17, 2016

Y-box-binding protein 1 (YB-1) and its functions.

I A Eliseeva1, E R Kim, S G Guryanov

  • 1Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.

Biochemistry. Biokhimiia
|February 21, 2012
PubMed
Summary

Y-box binding protein 1 (YB-1) is a multifunctional protein involved in DNA repair, transcription, and translation. This review details its roles in cancer, embryogenesis, and potential therapeutic applications.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Y-box binding protein 1 (YB-1) is a key transcription factor and RNA-binding protein.
  • YB-1 regulates gene expression at multiple levels, including DNA, mRNA, and protein interactions.
  • Its diverse functions are critical in cellular processes and disease development.

Purpose of the Study:

  • To comprehensively review the structure, functions, and interactions of Y-box binding protein 1 (YB-1).
  • To systematize data on YB-1's roles in DNA repair, transcription, mRNA processing, and cellular localization.
  • To explore YB-1's involvement in cell differentiation, signaling, embryogenesis, and oncogenesis.

Main Methods:

  • Literature review and data systematization.
  • Analysis of YB-1 interactions with DNA, mRNA, proteins, and cytoskeleton.
  • Summary of studies on YB-1 intracellular distribution, secretion, and extracellular functions.

Main Results:

  • YB-1 participates in DNA repair, transcription, mRNA splicing, and translation.
  • YB-1 interacts with cytoskeleton and influences mRNA localization.
  • YB-1 regulates cell differentiation, signaling pathways, and embryogenesis.
  • YB-1 exhibits both oncogenic and antioncogenic activities, impacting tumor drug resistance and metastasis.

Conclusions:

  • YB-1 is a versatile protein with critical roles in fundamental cellular processes and development.
  • YB-1's dual role in cancer highlights its complex involvement in oncogenic transformation and tumor progression.
  • YB-1 holds potential as an early cancer biomarker and a therapeutic target.