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Related Concept Videos

Overview of the Vascular System01:20

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
Contact-dependent Signaling01:19

Contact-dependent Signaling

Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
Plasmodesmata01:20

Plasmodesmata

In a multicellular organism, cells must communicate to work together in a coordinated manner. One way that cells communicate is through direct contact with other cells. The points of contact that connect adjacent cells are called intercellular junctions.
Intercellular junctions are a feature of fungal, plant, and animal cells. However, different types of junctions are found in different kinds of cells. Intercellular junctions found in animal cells include tight junctions, gap junctions, and...
Plasmodesmata02:32

Plasmodesmata

The organs in a multicellular organism’s body are made up of tissues formed by cells. To work together cohesively, cells must communicate. One way that cells communicate is through direct contact with other cells. The points of contact that connect adjacent cells are called intercellular junctions.
What is Cell Signaling?02:03

What is Cell Signaling?

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.

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Micropatterning and Assembly of 3D Microvessels
13:05

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Published on: September 9, 2016

Intercellular communication in the vascular wall: a modeling perspective.

Sridevi Nagaraja1, Adam Kapela, Nikolaos M Tsoukias

  • 1Department of Biomedical Engineering, Florida International University, Miami, Florida 33174, USA.

Microcirculation (New York, N.Y. : 1994)
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

Theoretical models help quantify ion and molecule movement in microcirculation signaling. These models enhance understanding of vascular phenomena like vasomotion and conducted responses.

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Area of Science:

  • Physiology
  • Biophysics
  • Computational Biology

Background:

  • Cellular signaling in microcirculation relies on ion (Ca2+, K+, Na+, Cl-) and second messenger (inositol 1,4,5-trisphosphate) fluxes.
  • Quantifying these intra- and intercellular fluxes and their physiological roles in microcirculatory phenomena remains a significant challenge.

Purpose of the Study:

  • To review theoretical models for estimating ionic and second messenger fluxes within and between cells.
  • To enhance the understanding of the physiological importance of these fluxes in microcirculation.

Main Methods:

  • Review of selected theoretical models focusing on calcium dynamics and plasma membrane electrophysiology.
  • Application of models to quantify intra- and intercellular fluxes.

Main Results:

  • Models provide a means to estimate the magnitude of ion and second messenger fluxes.
  • Models aid in predicting the significance of these fluxes to vascular phenomena.

Conclusions:

  • Theoretical models are crucial tools for understanding microcirculatory signaling.
  • These models advance our knowledge of myoendothelial feedback, conducted responses, and vasomotion.