Postorthodontic external root resorption in root-filled teeth is influenced by interleukin-1β polymorphism

Area of Science:

• Genetics
• Orthodontics
• Endodontics

Background:

• External apical root resorption (EARR) is a common complication of orthodontic treatment, with significant individual variability.
• Previous studies linked genetic variants in the interleukin-1 (IL1) gene to EARR in vital teeth.
• The response of endodontically treated teeth to orthodontic forces regarding EARR remains unclear.

Purpose of the Study:

• To investigate the influence of genetic variants in the interleukin-1 gene on EARR in endodontically treated teeth during orthodontic treatment.
• To determine if specific single nucleotide polymorphisms (SNPs) in the IL1 gene are associated with increased or decreased risk of EARR in root-filled teeth.

Main Methods:

• Genetic screening of 93 orthodontic patients for two IL1 gene SNPs (rs1800587, rs1143634).
• Patients were categorized based on radiographic evidence of >2 mm EARR on root-filled teeth post-treatment.
• Logistic regression analysis was employed to assess the association between IL1 polymorphisms and EARR, calculating odds ratios and confidence intervals.

Main Results:

• No significant association was found between EARR in root-filled teeth and genetic variations in IL1A.
• A significant direct relationship was observed for the IL1B gene (rs1143634): homozygous genotypes (TT and CC) were associated with an increased risk of EARR.
• Specific odds ratios indicated a substantially higher risk for homozygous carriers (OR=11.59 for TT, OR=2.54 for CC).

Conclusions:

• Genetic variations in the interleukin-1 beta (IL1B) gene, specifically rs1143634, may contribute to the development of EARR in endodontically treated teeth during orthodontic treatment.
• The findings suggest a genetic predisposition to EARR in root-filled teeth, linked to specific IL1B gene polymorphisms.