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Related Concept Videos

Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
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Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Notch Signaling Pathway03:14

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Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
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Purification of the Dendritic Filopodia-rich Fraction
11:51

Purification of the Dendritic Filopodia-rich Fraction

Published on: May 2, 2019

Sortilin: a receptor to regulate neuronal viability and function.

Anders Nykjaer1, Thomas E Willnow

  • 1The Lundbeck Foundation Research Centre MIND, Department of Biomedicine, University of Aarhus, Ole Worms Allé 1170, DK-8000 Aarhus C, Denmark. an@biokemi.au.dk

Trends in Neurosciences
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

Sortilin, a neuronal receptor, regulates nerve cell function and viability. This review highlights its roles in cellular transport, signaling, and nervous system health during injury and disease.

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Last Updated: May 24, 2026

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Sortilin is a type-1 receptor found in the central and peripheral nervous systems.
  • Initially viewed as an intracellular sorting protein, sortilin is now recognized for its crucial role in neuronal regulation.

Purpose of the Study:

  • To review recent findings on sortilin's functions in cellular transport and signaling.
  • To discuss sortilin's involvement in the nervous system's physiological integrity, injury, and disease.

Main Methods:

  • Literature review of recent research on sortilin.
  • Analysis of sortilin's roles as a receptor and co-receptor.
  • Examination of sortilin's contribution to neuronal viability and function.

Main Results:

  • Sortilin acts as a receptor for neurotrophic factors and neuropeptides.
  • Sortilin functions as a co-receptor for various signaling molecules, including cytokine receptors and tyrosine receptor kinases.
  • Sortilin is implicated in cellular transport and signaling pathways within neurons.

Conclusions:

  • Sortilin is essential for maintaining neuronal viability and function.
  • Sortilin plays a significant role in the nervous system under both normal and pathological conditions.
  • Understanding sortilin's multifaceted roles offers insights into neuronal health and disease.