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Related Experiment Video

Updated: May 24, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Novel insights into lipid antigen presentation.

Gennaro De Libero¹, Lucia Mori

¹Singapore Immunology Network, A*STAR, Singapore 138648, Singapore. Gennaro_delibero@immunol.a-star.edu.sg

Trends in Immunology

|February 21, 2012

Summary

T cells that recognize lipid antigens play key roles in immunity. This review details how CD1 molecules present these lipid antigens, advancing our understanding of lipid-specific immunity.

Area of Science:

Immunology
Molecular Biology
Cell Biology

Background:

T cells recognizing lipid antigens are abundant in blood and crucial for immune responses.
These T cells are involved in immunoregulation, tumor surveillance, and infection protection.

Purpose of the Study:

To review recent advancements in understanding lipid antigen presentation by CD1 molecules.
To explore the mechanisms of CD1 trafficking, lipid handling, and antigen loading.

Main Methods:

Review of recent studies on CD1 molecule structure and function.
Analysis of cellular mechanisms involved in lipid antigen processing and presentation.
Investigation of pathogen evasion strategies related to CD1-mediated immunity.

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Antigenic Liposomes for Generation of Disease-specific Antibodies

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Published on: October 25, 2018

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation

Published on: December 31, 2007

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

Main Results:

Detailed insights into CD1 trafficking, maturation, and lipid antigen loading.
Structural resolution of human CD1 molecules revealing unique functional features.
Elucidation of molecular mechanisms regulating CD1 expression and pathogen evasion tactics.

Conclusions:

Significant progress has been made in decoding lipid-specific immunity.
CD1-mediated lipid antigen recognition plays a vital immunological role.