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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

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Open ring enhancement in atypical brain demyelination.

Vijayakumar Javalkar¹, Marc Manix, Jon Wilson

¹Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71103-33932, USA.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia

|February 21, 2012

Summary

Open ring enhancement on MRI is specific for atypical demyelination. This case highlights its role in diagnosing tumefactive multiple sclerosis, differentiating it from tumors and abscesses.

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Area of Science:

Neurology
Radiology
Neuroimaging

Background:

Atypical demyelination presents diagnostic challenges.
Open ring enhancement is a key imaging finding.
Differentiating demyelinating lesions from neoplasms and abscesses is crucial.

Observation:

A patient presented with headache, ataxia, and lower extremity sensory disturbances.
Cranial MRI revealed a large frontal lesion with mass effect and midline shift.
The lesion exhibited characteristic open ring enhancement.

Findings:

The observed imaging features are indicative of tumefactive multiple sclerosis.
Open ring enhancement is a specific marker for atypical demyelination.
This pattern aids in distinguishing tumefactive MS from other intracranial pathologies.

Implications:

Open ring enhancement is a valuable sign in neuroimaging for diagnosing tumefactive MS.
Accurate differentiation prevents misdiagnosis and guides appropriate treatment strategies.
This finding underscores the importance of detailed MRI analysis in neurological assessments.