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The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

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Compliance With Preferred Reporting Items for Systematic Review and Meta-Analysis Individual Participant Data

Fareed Jumah¹, Silky Chotai², Omar Ashraf¹

¹Department of Neurosurgery, Rutgers- Robert Wood Johnson Medical School & University Hospital, New Brunswick, NJ (F.J., O.A., M.S.R., B.R., A.G., H.S., V.N., G.G., A.N.).

|June 4, 2021

Summary

Compliance with reporting guidelines for individual-participant data meta-analyses in stroke studies is suboptimal. Improving adherence to PRISMA-IPD guidelines is crucial for enhancing the quality of evidence synthesis in stroke research.

Keywords:

bias checklist guidelines adherence publication stroke

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Area of Science:

Medical research methodology
Evidence synthesis
Stroke research

Background:

Individual-participant data meta-analyses (IPD-MA) are the gold standard for evidence synthesis.
The Preferred Reporting Items for Systematic Review and Meta-Analysis of Individual Participant Data (PRISMA-IPD) guidelines ensure reporting quality.
Assessing compliance with PRISMA-IPD is vital due to the increasing number of IPD-MA in stroke.

Purpose of the Study:

To evaluate the adherence of published IPD-MA stroke studies to the PRISMA-IPD guidelines.
To identify specific areas of poor compliance within the PRISMA-IPD statement for stroke IPD-MA.
To explore factors associated with compliance to PRISMA-IPD in stroke research.

Main Methods:

Searched PubMed and EMBASE for stroke IPD-MA published between January 2016 and March 2020.
Excluded literature reviews, scoping reviews, and aggregate meta-analyses.
Scored 31 eligible studies using the 31-item PRISMA-IPD checklist and analyzed compliance.

Main Results:

Only 13% of studies explicitly mentioned using PRISMA-IPD guidelines.
42% of studies met all IPD-specific compliance criteria.
Poorest compliance was observed in bias assessment (32-39%), protocol/registration (42%), and IPD integrity (48%).

Conclusions:

Compliance with PRISMA-IPD guidelines in stroke IPD-MA is suboptimal.
No association was found between compliance and journal impact factor, author, or study characteristics.
Enhanced scrutiny and adherence measures are recommended to improve reporting quality in stroke IPD-MA.