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Synthesis of DNA interstrand cross-links using a photocaged nucleobase
Sarah Hentschel1, Jawad Alzeer, Todor Angelov
1Institute of Organic Chemistry, University of Zurich, Switzerland.
Abstract:
The missing linking: BCNU is a chemotherapy drug that generates an ethylene bridge between N(1) of deoxyguanosine and N(3) of deoxycytidine. No synthesis of a DNA containing this moiety has been reported until now. A new strategy uses a photocaged nucleobase that, when released, generates a highly reactive intermediate which cross-links the opposing DNA strand in a manner analogous to BCNU.
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