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Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Updated: May 24, 2026

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing
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Optical microspherical resonators for biomedical sensing.

Silvia Soria1, Simone Berneschi, Massimo Brenci

  • 1MDF Lab, Istituto di Fisica Applicata Nello Carrara (IFAC CNR), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. s.soria@ifac.cnr.it

Sensors (Basel, Switzerland)
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

Whispering gallery mode resonators, utilizing total internal reflection in microspheres, offer high quality factors for advanced optical applications. These high-Q resonators show promise in laser cavities, filters, and highly sensitive biosensors.

Keywords:
biomedical sensorsmicrospheresoptical resonatorswhispering gallery modes

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Area of Science:

  • Optics and Photonics
  • Biomedical Sensing

Background:

  • Optical resonators are crucial in modern optics.
  • Microspherical dielectric structures support whispering gallery modes (WGMs) via total internal reflection.
  • WGMs enable exceptionally high quality factors (Q) due to low loss, leading to high energy density and narrow spectral lines.

Purpose of the Study:

  • To analyze the characteristics, fabrication, and light coupling of microspherical resonators.
  • To overview recent advances in microspherical biosensors.
  • To highlight biomedical applications of these sensors.

Main Methods:

  • Analysis of microspherical resonator properties.
  • Review of fabrication techniques for microspheres.
  • Discussion of light coupling methods for WGMs.
  • Overview of recent developments in microspherical biosensor technology.

Main Results:

  • Microspherical resonators exhibit high Q-factors, making them suitable for lasers and filters.
  • These resonators are highly sensitive, enabling their use as biosensors.
  • Recent advances focus on enhancing sensitivity and specificity for biomedical applications.

Conclusions:

  • Microspherical resonators with whispering gallery modes are versatile optical components.
  • Their high Q-factor and sensitivity make them ideal for advanced sensing, particularly in the biomedical field.
  • Continued development promises significant advancements in biosensing technologies.