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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

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Published on: February 16, 2018

Waveguide-based biosensors for pathogen detection.

Harshini Mukundan¹, Aaron S Anderson, W Kevin Grace

¹Physical Chemistry and Applied spectroscopy, Chemistry Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.

Sensors (Basel, Switzerland)

|February 21, 2012

Summary

This summary is machine-generated.

Optical waveguides enhance biosensing by using evanescent fields for sensitive detection of biomolecules. This review covers principles, commercialized, and emerging technologies for optical biosensor development.

Keywords:

biosensors fluorescence immunoassay pathogen sensor planar optical waveguides thin film

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Area of Science:

Optoelectronics
Biomedical Engineering
Analytical Chemistry

Background:

Optical phenomena like fluorescence are crucial for biosensing.
Optical waveguides confine light via total internal reflection, generating evanescent fields.
Evanescent fields enable sensitive biomolecule detection by exciting fluorophores near the waveguide surface, minimizing background noise.

Purpose of the Study:

To review planar optical waveguide-based biodetection technologies.
To discuss principles, advantages, and disadvantages of these technologies.
To explore assay approaches, functionalization coatings, and alternative waveguide transducer designs.

Main Methods:

Review of existing literature and commercialized technologies.
Analysis of waveguide principles and evanescent field interactions.
Discussion of various assay strategies and thin-film coating applications.

Main Results:

Planar optical waveguides offer sensitive detection of biomolecules by minimizing background noise.
Both established (e.g., EPIC, BIND) and emerging waveguide technologies are presented.
Diverse assay formats and functionalization techniques are crucial for effective biosensing.

Conclusions:

Planar optical waveguides are a versatile platform for advanced biosensing.
Further research into novel waveguide designs and functionalization methods will drive innovation.
Optical waveguide technology holds significant promise for sensitive and specific biomolecule detection.