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Updated: May 24, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
(E)-4-Fluoro-2-[(4-hy-droxy-pheneth-yl)imino-meth-yl]phenol
Abstract:
The title compound, C(15)H(14)FNO(2), has an E conformation about the C=N bond, which facilitates the formation of an intra-molecular O-H⋯N hydrogen bond. The F atom is disordered over two adjacent sites in a 0.65 (7):0.35 (7) ratio. The dihedral angle between the benzene ring planes is 14.2 (2)°. In the crystal, mol-ecules are linked by O-H⋯O hydrogen bonds, forming C(14) [010] chains.
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Structure and Nomenclature of Alcohols and Phenols
Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
As with other organic compounds, alcohols and phenols...
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Acidity and Basicity of Alcohols and Phenols
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Hydrolysis of Chlorobenzene to Phenol: Dow Process
Halogens