Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...
Aromatic Hydrocarbon Cations: Structural Overview01:18

Aromatic Hydrocarbon Cations: Structural Overview

Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group with both...
Aryldiazonium Salts to Azo Dyes: Diazo Coupling01:11

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para position.
Nomenclature of Aromatic Compounds with Multiple Substituents01:11

Nomenclature of Aromatic Compounds with Multiple Substituents

When more than one substituent is present on the benzene ring, the IUPAC nomenclature depends on the number of substituents present.
For disubstituted benzene derivatives, with two groups attached to the benzene ring, three constitutional isomers are possible. For example, consider dimethyl benzene, often called xylene, where the second methyl group can be substituted at the second, third, or fourth carbon. The relative position of the substituents is represented by prefixes ortho, meta, or...
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene01:13

Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene

Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN101:14

Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1

Treating arylamines with nitrous acid gives aryldiazonium salts that are effective substrates in nucleophilic aromatic substitution reactions. The diazonio group in these salts can be easily displaced by different nucleophiles, yielding a wide variety of substituted benzenes. The leaving group departs as nitrogen gas, and this easy elimination is the driving force for the substitution reaction.
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo, or cyano...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis, crystal structure and Hirshfeld surface analysis of 2-(2,5-dioxo-4,4-di-phenyl-imidazolidin-1-yl)-<i>N</i>-(4-fluoro-phen-yl)acetamide (phenytoin analog).

Acta crystallographica. Section E, Crystallographic communications·2026
Same author

Synthesis, crystal structure and Hirshfeld surface analysis of <i>N</i>-(2,6-di-methyl-phen-yl)-2-morpholinoacetamide, a Lidocaine analog.

Acta crystallographica. Section E, Crystallographic communications·2026
Same author

Antioxidant and antifungal properties of flower and fruit extracts of <i>Arbutus unedo</i> L. from Morocco.

Natural product research·2026
Same author

Crystal structure and Hirshfeld surface analyses, inter-action energy calculations and energy frameworks of (<i>Z</i>)-4-benzyl-2-(4-methyl-benzylidene)-2<i>H</i>-[1,4]benzo-thia-zin-3(4<i>H</i>)-one.

Acta crystallographica. Section E, Crystallographic communications·2026
Same author

An analogue of indapamide: crystal structure and Hirshfeld surface analysis of 3-chloro-4-(<i>N</i>,<i>N</i>-diethynylsulfamo-yl)-<i>N</i>-(2-meth-yl-indolin-1-yl)benzamide.

Acta crystallographica. Section E, Crystallographic communications·2026
Same author

1-Ethenyl-2-(methyl-sulfan-yl)-4,4-diphenyl-4,5-di-hydro-1<i>H</i>-imidazol-5-one (Thio-phenytoin analogue): synthesis, structure and Hirshfeld surface analysis.

Acta crystallographica. Section E, Crystallographic communications·2026

Related Experiment Video

Updated: May 24, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
11:51

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

2-Phenyl-thieno[2,3-b]quinoxaline.

Youssef Ramli, Hafid Zouihri, Mohamed Azougagh

    Acta Crystallographica. Section E, Structure Reports Online
    |February 21, 2012
    PubMed
    Summary
    This summary is machine-generated.

    This study details the crystal structure of a novel organic compound, C(16)H(10)N(2)S. The research reveals its near-planar molecular geometry and a unique disorder in the thiophene ring sulfur atom.

    More Related Videos

    Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
    07:12

    Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions

    Published on: July 17, 2020

    Green Synthesis of Quinoline-Based Ionic Liquid
    05:59

    Green Synthesis of Quinoline-Based Ionic Liquid

    Published on: September 27, 2024

    Related Experiment Videos

    Last Updated: May 24, 2026

    Facile Preparation of 4-Substituted Quinazoline Derivatives
    11:51

    Facile Preparation of 4-Substituted Quinazoline Derivatives

    Published on: February 15, 2016

    Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
    07:12

    Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions

    Published on: July 17, 2020

    Green Synthesis of Quinoline-Based Ionic Liquid
    05:59

    Green Synthesis of Quinoline-Based Ionic Liquid

    Published on: September 27, 2024

    Area of Science:

    • Crystallography
    • Organic Chemistry
    • Materials Science

    Background:

    • Understanding the three-dimensional structure of organic molecules is crucial for predicting their properties and applications.
    • The compound C(16)H(10)N(2)S represents a class of molecules with potential applications in various fields.
    • Previous structural data for similar compounds may not fully capture the nuances of this specific molecule.

    Purpose of the Study:

    • To elucidate the precise molecular structure of the title compound, C(16)H(10)N(2)S.
    • To investigate the planarity and any deviations from it in the molecular framework.
    • To characterize the crystallographic disorder observed in the thiophene ring.

    Main Methods:

    • Single-crystal X-ray diffraction was employed to collect diffraction data.
    • The crystal structure was solved and refined using standard crystallographic software.
    • Analysis of atomic coordinates and bond parameters provided insights into molecular geometry.

    Main Results:

    • The title compound, C(16)H(10)N(2)S, exhibits a near-planar conformation with an r.m.s. deviation of 0.080 Å for non-hydrogen atoms.
    • A small dihedral angle of 9.26(3)° was measured between the fused-ring system and the phenyl ring.
    • Significant crystallographic disorder was identified in the thiophene ring, with the sulfur atom and its opposite carbon atom disordered in a 0.77:0.23 ratio.

    Conclusions:

    • The structural analysis confirms the near-planar nature of C(16)H(10)N(2)S, influenced by the fused-ring and phenyl moieties.
    • The observed disorder in the thiophene ring is a key feature that may impact the compound's physical and chemical properties.
    • This detailed structural information provides a foundation for further research into the compound's potential applications.