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Bacteremia among Jordanian children at Princess Rahmah Hospital: Pathogens and antimicrobial susceptibility patterns
1Faculty of Nursing, Irbid National University, Irbid, Jordan.
Insights
Staphylococcus aureus was the most common cause of bacteremia in Jordanian children. All identified S. aureus strains remained susceptible to vancomycin, guiding effective empirical therapy choices.
Area of Science:
- Pediatric Infectious Diseases
- Clinical Microbiology
- Antimicrobial Resistance
Background:
- Bacteremia poses a significant threat to children's health.
- Understanding local etiological patterns and antimicrobial susceptibility is crucial for effective treatment.
Purpose of the Study:
- To identify causative agents of bacteremia in Jordanian children.
- To evaluate the antimicrobial susceptibility profiles of these pathogens.
Main Methods:
- Retrospective analysis of 378 positive blood cultures from children under 15.
- Data collected from Princess Rahmah Hospital between January and December 2008.
Main Results:
- Staphylococcus aureus was the predominant pathogen (86.2%).
- Klebsiella spp. and Escherichia coli were other significant isolates.
- S. aureus showed high susceptibility (99.6%) to vancomycin but low susceptibility (3.2%) to aztreonam.
Conclusions:
- Staphylococcus aureus is the primary cause of bacteremia in this pediatric cohort.
- Vancomycin remains highly effective against S. aureus bacteremia.
- High aztreonam resistance necessitates careful consideration in empirical treatment strategies.
Objective:
To investigate microorganisms causing bacteremia in Jordanian children and to assess their sensitivity to various groups of antimicrobials.
Methods:
A retrospective study was conducted on positive blood cultures taken from 378 children aged below 15 year, who sought medical attention at Princess Rahmah Hospital between January and December/2008.
Results:
Out of 4475 tested blood samples, 378 isolates were recovered from blood cultures. The male to female isolate ratio was (1.26:1.0). The most frequent pathogen found was Staphylococcus aureus (86.2%), followed by Klebsiella spp. (9%), Escherichia coli (1.9%), Streptococcus spp. (1.9%), Pseudomonas spp. (0.8%), and Acinetobacter sp. was found in only one culture (0.3%). The susceptibility rate of S. aureus was recorded the highest (99.6%) for vancomycin, and the lowest susceptibility rate (3.2%) was recorded for aztreonam.
Conclusions:
Staphylococcus aureus was the main isolate in bacteremic children, with all isolates demonstrating susceptibility to vancomycin. Overall, aztreonam resistance was near 97%, and this rate was not affected by sex and blood isolate type. This information should be considered when empirical therapy is recommended or prescribed for children with bacteremia.
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