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Updated: May 24, 2026

Imaging and Analysis of Oil Red O-Stained Whole Aorta Lesions in an Aneurysm Hyperlipidemia Mouse Model
Published on: May 2, 2022
Diffuse involvement of aorta in patient with familial hyperlipidemia
Mehmet Mustafa Can1, Ibrahim Halil Tanboga, Taylan Akgun
1GATA Haydarpasa Research and Training Hospital, 81327 Istanbul, Turkey.
Abstract:
Familial hyperlipidemia (FH) is an inherited metabolic disorder caused by low-density lipoprotein (LDL) receptor abnormality. The delayed clearance of serum LDL results in severe hypercholesterolemia, which leads to the accumulation of LDL-derived cholesterol in skin, tendons, and arterial walls.In homozygous form of the disease, severely atheromatous involvement of the aorta extending to the coronary ostia is almost always present, and particular surgical strategy is required to prevent atheroembolic events.
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