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Updated: May 24, 2026

Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
Published on: May 16, 2021
Creatine-induced glucose uptake in type 2 diabetes: a role for AMPK-α?
Christiano Robles Rodrigues Alves1, Júlio César Ferreira, Mário Alves de Siqueira-Filho
1School of Physical Education and Sports, University of Sao Paulo, Av Mello de Moraes, 65-Butantã, Sao Paulo, SP, 05508-030, Brazil.
Abstract:
This study focused on understanding the signaling mechanisms leading to GLUT-4 translocation and increased skeletal-muscle glucose uptake that follow creatine (Cr) supplementation in type 2 diabetes (n = 10). AMPK-α protein content presented a tendency to be higher (p = 0.06) after Cr supplementation (5 g/d for 12w). The changes in AMPK-α protein content significantly related (p < 0.001) to the changes in GLUT-4 translocation (r = 0.78) and Hb1Ac levels (r = -0.68), suggesting that AMPK signaling may be implicated in the effects of supplementation on glucose uptake in type 2 diabetes.
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