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Decrease in circulating endothelial progenitor cells in treated glioma patients.

Elena Corsini1, Emilio Ciusani, Paola Gaviani

  • 1Laboratory of Clinical Pathology and Medical Genetics, Fondazione IRCCS Istituto Neurologico C. Besta, Via Celoria 11, 20133, Milano, MI, Italy.

Journal of Neuro-Oncology
|February 22, 2012
PubMed
Summary

Circulating endothelial progenitor cells (EPCs) decrease after glioma treatment. While vascular endothelial growth factor (VEGF) is higher in glioma patients, its levels are reduced by surgery but not chemotherapy, with no correlation to EPCs.

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Area of Science:

  • Neuro-oncology
  • Vascular Biology
  • Cancer Therapy

Background:

  • High-grade gliomas exhibit significant neovascularization, correlating with malignancy.
  • The role of endothelial progenitor cells (EPCs) in glioma angiogenesis and treatment response remains unclear.

Purpose of the Study:

  • To investigate the impact of surgery and post-surgical therapies on circulating EPC levels in glioma patients.
  • To assess the correlation between EPCs, vascular endothelial growth factor (VEGF), and glioma treatment status.

Main Methods:

  • Flow cytometry was used to quantify EPCs in 78 high-grade glioma patients (untreated and treated) and 34 healthy controls.
  • VEGF plasma levels were also measured in all participants.

Main Results:

  • Circulating EPCs were significantly lower in treated glioma patients compared to untreated patients.
  • VEGF levels were elevated in patients versus controls; surgery reduced VEGF, but chemotherapy did not.
  • No significant correlation was observed between plasma VEGF levels and EPC counts.

Conclusions:

  • Post-surgical treatment, including radiotherapy and chemotherapy, leads to a decrease in circulating EPCs in high-grade glioma patients.
  • Surgery effectively reduces VEGF levels, suggesting a role in controlling tumor vasculature, while chemotherapy's effect on VEGF is less pronounced.
  • The utility of EPCs as a sole biomarker for monitoring glioma-related angiogenesis requires further investigation, particularly concerning their correlation with other angiogenic markers.