Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

Inflammatory Bowel Disease III: Crohn's Disease

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

Myasthenia Gravis ll: Pathophysiology

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

No serological association between Porphyromonas gingivalis or Prevotella intermedia and early spondyloarthritis: analysis from the DESIR cohort.

Clinical and experimental medicine·2026

Same author

Positive and Negative Cardiovascular Effects of JAK Inhibitors in Inflammation.

ACR open rheumatology·2026

Same author

Postmenopausal Osteoporosis, Endothelial Dysfunction, and Cardiovascular Risk.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2026

Same author

Correction: Filali et al. Morphological and Mechanical Characterization of Extracellular Vesicles and Parent Human Synoviocytes under Physiological and Inflammatory Conditions. <i>Int. J. Mol. Sci.</i> 2022, <i>23</i>, 13201.

International journal of molecular sciences·2026

Same author

Bacterial translocation and intestinal permeability in early axial spondyloarthritis association with 5-year outcomes: insights from the DESIR cohort.

Rheumatology (Oxford, England)·2026

Same author

Longitudinal incidence of native septic arthritis in France: a 13-year analysis of the National Health Data System Database.

Rheumatology (Oxford, England)·2026

Search research articles

Related Experiment Video

Updated: May 24, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Interleukin-17 in inflammatory myopathies.

Anne Tournadre¹, Pierre Miossec

¹Department of Clinical Immunology and Rheumatology, Hôpital Edouard Herriot, Lyon, France.

Current Rheumatology Reports

|February 22, 2012

Summary

Interleukin-17 (IL-17) plays a key role in chronic inflammation, particularly in inflammatory myopathies. Targeting the IL-23/T-helper 17 (Th17) pathway shows promise for treating these debilitating muscle diseases.

Area of Science:

Immunology
Rheumatology
Cell Biology

Background:

The T-helper 17 (Th17) pathway, involving interleukin-17 (IL-17), is implicated in chronic inflammatory diseases like rheumatoid arthritis.
While T-helper 1 (Th1) responses were initially suspected in inflammatory myopathies, recent findings suggest a role for IL-17.

Purpose of the Study:

To investigate the involvement of the IL-23/Th17 pathway in inflammatory myopathies.
To explore IL-17 as a potential therapeutic target for myositis.

Main Methods:

Analysis of IL-17-producing cells and dendritic cells in inflamed muscle tissue.
In vitro studies examining the effects of IL-17 on muscle cells.

Main Results:

Evidence suggests local activation of the IL-23/Th17 pathway in myositis lesions.

Related Experiment Videos

Last Updated: May 24, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

IL-17, along with other pro-inflammatory cytokines, can amplify immune responses and potentially lead to muscle destruction.

In vitro studies confirm IL-17's effects on muscle cells.

Conclusions:

The IL-17 pathway is activated in inflammatory myopathies and contributes to muscle inflammation and destruction.
IL-17 inhibition presents a potential therapeutic strategy for inflammatory myopathies, although its precise role in treatment requires further definition.