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Updated: May 24, 2026
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Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation
Published on: March 17, 2023
Tricuspid regurgitation: pathophysiology and management
Rashmi Thapa1, Buddhadeb Dawn, Jayant Nath
1Division of Cardiovascular Diseases, University of Kansas Medical Center, Kansas City, KS 66160, USA. rthapa@kumc.edu
Current Cardiology Reports
|February 22, 2012
Summary
Tricuspid regurgitation (TR), a common heart valve issue, causes significant health problems when severe. New treatments are emerging, but a consensus on the best approach is lacking, especially with advancing percutaneous valve technology.
Area of Science:
- Cardiology
- Valvular Heart Disease
Background:
- Tricuspid regurgitation (TR) is a prevalent valvular heart condition.
- Severe TR significantly increases patient mortality and morbidity.
- Historically underestimated, TR now receives increased clinical attention.
Purpose of the Study:
- To review the pathophysiology and current management strategies for tricuspid regurgitation.
- To explore emerging and investigational treatment modalities for TR.
- To discuss the evolving clinical indications for TR treatment.
Main Methods:
- Literature review of pathophysiology and management of tricuspid regurgitation.
- Analysis of current and emerging treatment options, including percutaneous approaches.
- Discussion of factors influencing treatment indications, such as LVADs and RV function.
Main Results:
- TR is common, easily diagnosed by echocardiography, but severe cases lead to poor outcomes.
- Multiple treatment options exist, but no single approach is universally superior.
- Percutaneous atrioventricular valves represent a new frontier in TR management.
Conclusions:
- TR management is evolving, with no established treatment consensus.
- Advancements in percutaneous valves and supportive therapies (LVADs) are reshaping TR treatment paradigms.
- Further research into novel TR therapies is warranted.
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