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Updated: May 24, 2026

A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat
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A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat

Published on: October 6, 2018

New advances in MR-compatible bioartificial liver.

Rex E Jeffries1, Jeffrey M Macdonald

  • 1Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7575, USA.

NMR in Biomedicine
|February 22, 2012
PubMed
Summary

This study reviews 30 years of MR-compatible bioartificial liver (BAL) research, detailing methods for monitoring liver tissue engineering. Novel MR-compatible BALs and advanced imaging techniques enable noninvasive assessment of BAL growth, metabolism, and viability.

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Hepatology

Background:

  • Bioartificial liver (BAL) research has spanned three decades, focusing on metabolism, drug studies, and long-term liver tissue engineering.
  • Existing methods often require invasive procedures or specialized equipment for monitoring BAL systems.
  • Advancements in Magnetic Resonance (MR) technology offer potential for noninvasive assessment of BALs.

Purpose of the Study:

  • To review existing MR-compatible bioartificial liver (BAL) studies.
  • To present novel MR-compatible BAL designs and advanced MR techniques for BAL monitoring.
  • To describe a flexible coil design and life support system for making BALs MR-compatible.

Main Methods:

  • Utilizing multinuclear MRS ((13)C, (19)F, (31)P) for noninvasive monitoring of BAL growth, metabolism, and viability.

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  • Employing (1)H MRI methods to assess flow profiles, diffusion, cell distribution, quality assurance, and bioreactor integrity.
  • Developing and integrating MR-compatible radiofrequency probes and life support systems with bioreactors.

    • Main Results:

    • Demonstrated the capability of multinuclear MRS and (1)H MRI for comprehensive, noninvasive evaluation of BAL systems.
    • Presented novel MR-compatible BAL designs suitable for long-term liver tissue engineering.
    • Showcased a versatile coil and circuit design adaptable to various BAL configurations.

    Conclusions:

    • MR-compatible BAL technology has matured over 30 years, offering significant potential for liver tissue engineering.
    • Multinuclear MRS and (1)H MRI provide powerful tools for noninvasive monitoring and quality control of BALs.
    • The described innovations facilitate broader adoption of MR compatibility in BAL research and development.