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Updated: May 24, 2026
Intramyocardial Cell Delivery: Observations in Murine Hearts
Published on: January 24, 2014
Autologous bone marrow stem cell transplant in acute myocardial infarction
Muhammad Masudul Hassan Nuri1, Shahid Hafeez
1Department of Cardiology, Army Medical College, Rawalpindi.
Insights
Autologous bone marrow stem cell transplant improved clinical symptoms, left ventricle ejection fraction, and myocardial perfusion in patients with anterior myocardial infarction. This therapy appears safe and effective for post-heart attack recovery.
Area of Science:
- Cardiology
- Regenerative Medicine
- Interventional Cardiology
Background:
- Recent anterior myocardial infarction (MI) significantly impacts left ventricle (LV) function and myocardial perfusion.
- Limited therapeutic options exist to improve cardiac function post-MI.
Purpose of the Study:
- To evaluate the efficacy of autologous bone marrow stem cell transplantation in patients with recent anterior MI.
- To assess the impact on clinical symptoms, LV ejection fraction (LVEF), and myocardial perfusion.
Main Methods:
- 26 male patients with anterior MI underwent autologous bone marrow stem cell transplantation into the damaged myocardium.
- Stem cells were harvested from iliac crests and delivered via a stop-flow technique.
- Efficacy was assessed by comparing clinical status, LVEF, and myocardial perfusion at baseline and 12 weeks post-transplant.
Main Results:
- Significant improvement observed in general well-being.
- Left ventricle ejection fraction showed notable enhancement post-transplantation.
- Myocardial perfusion demonstrated positive changes following stem cell therapy.
Conclusions:
- Autologous bone marrow stem cell transplantation is a safe and favorable treatment for improving post-MI LVEF and perfusion.
- Further large-scale, randomized controlled trials are needed to confirm the efficacy and cost-effectiveness of this therapy.
Objective:
To evaluate the effects of autologous bone marrow stem cell transplant on clinical symptoms, overall left ventricle ejection fraction and myocardial perfusion in patients with recent anterior myocardial infarction in left anterior descending artery territory.
Methods:
The study was conducted in the department of interventional cardiology of Armed Forces Institute of Cardiology, National Institute of Heart Diseases (AFIC/NIHD), Rawalpindi from June 2004 to November 2006. There were 26 male patients with recent anterior myocardial infarction, having anterior/apical hypokinesia and disease process involving only left anterior descending artery, who were recruited. The whole procedure was explained to the patients in the language of their best understanding and informed consent was obtained. Stem cell harvest was obtained from both posterior superior iliac crests, which were processed to note total and mean mononuclear cell counts. Stem cells were transplanted into the damaged myocardium using stop flow technique through lumen of over-the-wire balloon catheter, placed in mid left anterior descending artery. All patients tolerated the procedure well except for a few complications which were tackled by the experienced operators. The patients were advised to continue conventional medical therapy. The efficacy of stem cell transplant was objectively assessed by comparing effects on three parameters--clinical, left ventricle cineangiographic, and nuclear scintigraphic status--at baseline and at 12 weeks after transplantation.
Results:
There is improvement in general well being, left ventricle ejection fraction and myocardial perfusion after stem cell therapy.
Conclusion:
Autologous bone marrow stem cell transplant seems to be a favourable and secure way of treatment for improvement of post-myocardial infarction ejection fraction and perfusion. There is dire need to conduct larger randomised controlled trials to assess efficacy of this cost-effective mode of therapy, especially in our part of the world.
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