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Updated: May 24, 2026
Intramyocardial Cell Delivery: Observations in Murine Hearts
Published on: January 24, 2014
Intracoronary administration of autologous bone marrow stem cell transplant in myocardial infarction
Muhammad Masud-ul-Hasan Nuri1, Shahid Hafeez
1Department of Cardiology, Army Medical College, Rawalpindi.
Insights
Autologous bone marrow stem cell transplantation via intracoronary infusion is a safe and effective treatment for acute myocardial infarction. This method improved clinical symptoms, left ventricle ejection fraction, and myocardial perfusion in patients.
Area of Science:
- Cardiovascular Medicine
- Regenerative Medicine
- Interventional Cardiology
Background:
- Acute myocardial infarction (AMI) remains a leading cause of mortality worldwide.
- Limited therapeutic options exist for myocardial repair post-infarction.
- Autologous stem cell transplantation offers a promising regenerative approach.
Purpose of the Study:
- To detail the technique of intracoronary administration of autologous bone marrow stem cells in AMI patients.
- To evaluate the safety and efficacy of this cell-based therapy.
Main Methods:
- Pilot study conducted from June 2004 to November 2006.
- Inclusion criteria: recent anterior AMI with anteroapical hypokinesia and single-vessel disease.
- Stem cells harvested from iliac crests, injected into the left anterior descending artery during transient balloon inflation.
Main Results:
- Procedure successfully performed and well-tolerated by all patients.
- Minor complications were managed effectively.
- Significant improvements observed in clinical symptoms, left ventricle ejection fraction, and myocardial perfusion at 12 weeks.
Conclusions:
- Intracoronary stem cell infusion is a simple, safe, and effective method for cell delivery in AMI.
- This technique shows potential for myocardial regeneration and functional recovery.
Objective:
To elaborate in detail the technique of intracoronary administration of autologous bone marrow stem cell transplantation in patients with acute myocardial infarction.
Methods:
This procedure was carried out during a pilot study which was conducted in the department of interventional cardiology of Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi from June 2004 to November 2006. The inclusion criteria's were recent anterior myocardial infarction with anteroapical hypokinesia and single vessel disease in left anterior descending artery. The informed consent was obtained. After giving local anaesthesia and light sedation, both posterior superior iliac crests were accessed by multiple punctures to get stem cell harvest. The harvest was analyzed to document total and mean mononuclear cell count. An over the wire balloon catheter was parked in mid left anterior descending artery. The stem cells were injected intermittently into the infarcted myocardium during transient balloon inflation over 45-60 minutes. The clinical, left ventricle cineangiographic and nuclear scintigraphic parameters were analyzed and compared at week 0 and 12 to objectively document the effects of stem cell.
Results:
The procedure was successfully carried out and well tolerated by all the patients. The minor complications were managed accordingly. Post autologous stem cell therapy, there was amelioration in clinical symptoms, left ventricle ejection fraction and myocardial perfusion.
Conclusion:
Intracoronary artery infusion of stem cells in acute myocardial infarction is simple, reasonably safe and effective mode of cell delivery in our set up.
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