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Living-donor liver transplant in 3 patients with Budd-Chiari syndrome: case report
Koray Bas1, Onur Yaprak, Murat Dayangac
1Department of General Surgery, Florence Nightingale Hospital, Organ Transplantation Center, Istanbul, Turkey. drkoraybas@yahoo.com
Insights
Budd-Chiari syndrome, a hepatic outflow obstruction, can be treated with liver transplant. Living-donor liver transplant offers a safe alternative when deceased donor grafts are unavailable for end-stage liver disease.
Area of Science:
- Hepatology and Transplant Surgery
- Vascular Surgery
Background:
- Budd-Chiari syndrome involves hepatic venous outflow obstruction, a critical condition requiring timely intervention.
- Treatment strategies are tailored to obstruction characteristics and liver function, often involving a stepwise approach.
Observation:
- This study details three cases of Budd-Chiari syndrome managed with living-donor liver transplantation.
- The cases highlight diagnostic and therapeutic pathways, potential complications, and patient outcomes.
Findings:
- Living-donor liver transplant is a viable and safe option for Budd-Chiari syndrome patients with end-stage liver disease, especially when deceased donor organs are scarce.
Implications:
- This research supports the expanded use of living-donor liver transplantation in managing complex cases of Budd-Chiari syndrome.
- It offers a crucial alternative for patients facing limited deceased donor graft availability, improving transplant accessibility.
Abstract:
Budd-Chiari syndrome is a rare but life-threatening disorder characterized by obstruction of the hepatic venous outflow. Treatment depends on the underlying cause, the location, and extent of the obstruction, and the functional capacity of the liver. A stepwise therapeutic approach is commonly accepted. When all other therapy options are unsuccessful, or in case of end-stage liver disease, transplant should be considered. We present case reports of 3 patients with Budd-Chiari syndrome who underwent living-donor liver transplant. Characteristic features of Budd-Chiari syndrome, diagnostic and therapeutic interventions, complications, and overall outcomes are discussed. We believe that when a deceased donor graft is unavailable, a living-donor liver transplant can be a safe option for patients with end-stage liver disease associated with Budd-Chiari syndrome.
