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Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

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Optofluidic concentration: plasmonic nanostructure as concentrator and sensor.

Carlos Escobedo¹, Alexandre G Brolo, Reuven Gordon

¹Department of Biosystems Science and Engineering, Bio Engineering Laboratory, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.

|February 23, 2012

Summary

This study uses nanohole arrays to actively concentrate analytes, significantly improving sensor detection limits and speed for faster, more sensitive molecular detection.

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Area of Science:

Nanotechnology
Analytical Chemistry
Biophysics

Background:

Fluidics and optics integration enhances analyte transport to sensing surfaces.
Local analyte concentration fundamentally limits detection.
Current methods face limitations in sensitivity and speed.

Purpose of the Study:

To develop a method for active analyte concentration within nanohole array sensors.
To overcome the limitations of local analyte concentration in sensing.
To enhance sensor sensitivity and speed.

Main Methods:

Utilizing nanohole array geometry for analyte manipulation.
Leveraging the conducting properties of the film for active concentration.
Employing flow-through systems for real-time analysis.

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Main Results:

Achieved 180-fold enrichment of a dye molecule.
Demonstrated 100-fold enrichment and simultaneous sensing of a protein.
Realized these results in under 1 minute.

Conclusions:

The developed method significantly enhances analyte concentration.
This approach offers potential for a 100-fold improvement in detection limits.
The technique promises an order of magnitude increase in sensing speed.