Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conductors and Insulators01:19

Conductors and Insulators

10.2K
Some materials may easily let electrical charges pass through them, while others obstruct their flow. The former are called conductors and the latter insulators. The atomic structures of materials determine whether they are conductors or insulators of electricity.
Most metals are conductors. Their atomic configuration is such that one or more electron(s) are loosely bound to the nucleus in each atom. Thus, a sea of mobile electrons are available in them, known as free electrons. Their easy...
10.2K
Dielectric Polarization in a Capacitor01:31

Dielectric Polarization in a Capacitor

5.7K
The presence of a dielectric medium in a capacitor not only changes the voltage and capacitance but also affects the electric field. In general, dielectrics can be of two types: polar and nonpolar. In a polar dielectric, the positive and negative charges in the molecules are separated by a distance and hence have a permanent dipole moment. In contrast, no such charge separation exists in a nonpolar dielectric, however the nonpolar molecules get polarized in the presence of an external electric...
5.7K
Insulation Coordination01:23

Insulation Coordination

490
Insulation coordination is the process of matching electric equipment's insulation strength with protective device characteristics to protect the equipment against expected overvoltages. This selection is based on engineering judgment and cost. Equipment can generally withstand short-duration high transient overvoltages, but repeated tests with identical waveforms can yield inconsistent results. As a result, standard impulse voltage waveforms are used for testing, defined by specific times...
490
Electrostatic Boundary Conditions in Dielectrics01:27

Electrostatic Boundary Conditions in Dielectrics

1.7K
When an electric field passes from one homogeneous medium to another, crossing the boundary between the two mediums imparts a discontinuity in the electric field. This results in electrostatic boundary conditions that depend on the type of mediums the field propagates through.
Consider a case where both the mediums across a boundary are two different dielectric materials. Recall that the electric field and electric displacement are proportional and related through the material's permittivity....
1.7K
Capacitor With A Dielectric01:18

Capacitor With A Dielectric

4.8K
Parallel plate capacitors consist of two conducting plates separated by a certain distance. However, it is mechanically difficult to hold the large plates parallel to each other without actual contact. Hence, a dielectric layer is commonly placed between the plates, which provides an easy solution for holding the plates together with a small gap and increases the capacitance of the capacitor.
Dielectrics are non-conducting materials with no free or loosely bound electrons. When a dielectric is...
4.8K
Inductance: Solid Cylindrical Conductor01:24

Inductance: Solid Cylindrical Conductor

761
To calculate the inductance of a solid cylindrical conductor, consider a 1-meter section of a non-magnetic, current-carrying conductor with radius r. Disregarding end effects and assuming uniform current density, Ampere's law helps determine the magnetic field inside the conductor. This law states that the magnetic field intensity H is concentric and constant within the conductor.
Given the uniform current distribution, the magnetic field Hx and flux density Bx inside the conductor are...
761

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A meta-analysis of carbon losses and gains from tropical moist forest degradation and regeneration.

Science advances·2026
Same author

Small molecule-mediated activation of Notch signal transduction.

Cell death & disease·2026
Same author

Spatial proteomics profiling reveals oncogene-specific immune niches and prognostic markers in NSCLC.

American journal of respiratory and critical care medicine·2026
Same author

Transcriptional landscape of pulmonary artery endothelium reveals subpopulation- and disease-specific remodeling signatures.

Communications biology·2026
Same author

Persistence of alveolar fibroblast-derived ADAMTS4+ cells in a preclinical model of delayed pulmonary fibrosis resolution.

Nature communications·2026
Same author

Novel Netrin-1-Unc5b-Klf4 axis balances AT2 survival in experimental bronchopulmonary dysplasia.

American journal of respiratory cell and molecular biology·2026
Same journal

Expanding the C. elegans toolkit with gonad explants.

Development (Cambridge, England)·2026
Same journal

Nuclear Factor Y controls nutrient-adaptive epithelial growth by regulating mTOR in the Drosophila midgut.

Development (Cambridge, England)·2026
Same journal

Primordial germ cells differentially contribute to the germline in zebrafish.

Development (Cambridge, England)·2026
Same journal

Dissecting planar and vertical organiser signals in early chick neural development.

Development (Cambridge, England)·2026
Same journal

Real-time transcriptomic profiling of hPSC-derived cartilage during development identifies a key role for the extracellular matrix in homeostasis and protection.

Development (Cambridge, England)·2026
Same journal

In preprints - housekeeping the housekeeping genes.

Development (Cambridge, England)·2026
See all related articles

Related Experiment Video

Updated: Dec 21, 2025

Thermal Scanning Conductometry TSC as a General Method for Studying and Controlling the Phase Behavior of Conductive Physical Gels
10:01

Thermal Scanning Conductometry TSC as a General Method for Studying and Controlling the Phase Behavior of Conductive Physical Gels

Published on: January 23, 2018

8.0K

CTCF: insights into insulator function during development.

Martin Herold1, Marek Bartkuhn, Rainer Renkawitz

  • 1Institut für Genetik, Justus-Liebig-Universität Giessen, Heinrich-Buff-Ring 58-62, 35392 Giessen, Germany.

Development (Cambridge, England)
|February 23, 2012
PubMed
Summary
This summary is machine-generated.

The CCCTC-binding factor (CTCF) protein acts as a master regulator, controlling gene activity across the genome. It shields genes and prevents interference, playing a key role in development.

More Related Videos

Effect of Bending on the Electrical Characteristics of Flexible Organic Single Crystal-based Field-effect Transistors
08:43

Effect of Bending on the Electrical Characteristics of Flexible Organic Single Crystal-based Field-effect Transistors

Published on: November 7, 2016

8.3K
In Situ Time-dependent Dielectric Breakdown in the Transmission Electron Microscope: A Possibility to Understand the Failure Mechanism in Microelectronic Devices
09:26

In Situ Time-dependent Dielectric Breakdown in the Transmission Electron Microscope: A Possibility to Understand the Failure Mechanism in Microelectronic Devices

Published on: June 26, 2015

9.1K

Related Experiment Videos

Last Updated: Dec 21, 2025

Thermal Scanning Conductometry TSC as a General Method for Studying and Controlling the Phase Behavior of Conductive Physical Gels
10:01

Thermal Scanning Conductometry TSC as a General Method for Studying and Controlling the Phase Behavior of Conductive Physical Gels

Published on: January 23, 2018

8.0K
Effect of Bending on the Electrical Characteristics of Flexible Organic Single Crystal-based Field-effect Transistors
08:43

Effect of Bending on the Electrical Characteristics of Flexible Organic Single Crystal-based Field-effect Transistors

Published on: November 7, 2016

8.3K
In Situ Time-dependent Dielectric Breakdown in the Transmission Electron Microscope: A Possibility to Understand the Failure Mechanism in Microelectronic Devices
09:26

In Situ Time-dependent Dielectric Breakdown in the Transmission Electron Microscope: A Possibility to Understand the Failure Mechanism in Microelectronic Devices

Published on: June 26, 2015

9.1K

Area of Science:

  • Genomics
  • Molecular Biology
  • Developmental Biology

Background:

  • Higher eukaryotes possess genomes with both active and inactive genes.
  • The CCCTC-binding factor (CTCF) protein binds insulator sequences.
  • CTCF prevents crosstalk between genomic regions and shields genes from enhancers.

Purpose of the Study:

  • To discuss developmentally regulated CTCF-dependent transcription mechanisms.
  • To highlight genome-wide results on CTCF's regulatory role.
  • To explore CTCF's function in embryonic, neuronal, and hematopoietic development.

Main Methods:

  • Review of existing literature on CTCF function.
  • Analysis of model gene systems.
  • Examination of genome-wide data.

Main Results:

  • CTCF plays a critical role in developmental processes.
  • CTCF acts as a master regulator of transcription.
  • CTCF influences both gene activation and repression genome-wide.

Conclusions:

  • CTCF is a key factor in regulating gene expression during development.
  • CTCF's functions are essential for normal embryonic, neuronal, and hematopoietic development.
  • CTCF's genome-wide regulatory role underscores its importance in higher eukaryotes.