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Updated: May 24, 2026

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta

Published on: September 27, 2017

Maternal obesity: improving pregnancy outcomes.

Priscilla M Nodine¹, Marie Hastings-Tolsma

¹School of Medicine, Department of Obstetrics and Gynecology, University of Colorado, Denver, Aurora, CO, USA. priscilla.nodine@ucdenver.edu

MCN. the American Journal of Maternal Child Nursing

|February 24, 2012

Summary

Maternal obesity (body mass index ≥ 30) increases risks for infertility, fetal anomalies, and gestational diabetes. Healthcare providers can improve prenatal care and outcomes for obese pregnant women and their children.

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Area of Science:

Obstetrics and Gynecology
Public Health
Reproductive Medicine

Background:

Obesity affects approximately 30% of pregnant women, posing significant health risks.
Maternal obesity is linked to adverse pregnancy outcomes and long-term health issues for offspring.
Understanding these risks is crucial for effective prenatal care and management.

Purpose of the Study:

To review obstetrical risks associated with maternal obesity.
To assess prevention and management strategies for pregnant women with obesity.
To highlight the role of healthcare providers in improving outcomes.

Main Methods:

Literature review of select obstetrical risks.
Assessment of current prevention and management guidelines.
Discussion of the role of nurses, nurse practitioners, and nurse-midwives.

Main Results:

Maternal obesity is associated with infertility, fetal anomalies, gestational hypertensive diseases, gestational diabetes, intrauterine fetal death, cesarean birth, and macrosomia.
Adverse outcomes are attributed to maternal body habitus, obesity-induced inflammation, and metabolic dysfunction.
Prenatal care and management strategies can mitigate risks and improve outcomes.

Conclusions:

Maternal obesity presents numerous obstetrical challenges requiring targeted interventions.
Healthcare providers play a vital role in managing maternal obesity during pregnancy.
Effective management can positively influence the health of both mother and child.