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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
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Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
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Updated: May 24, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
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Pediatric oncology situation analysis (Jordan).

Hala Saleh Al-Rimawi1

  • 1Department of Pediatric, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan. dima@just.edu.jo

Journal of Pediatric Hematology/Oncology
|February 24, 2012
PubMed
Summary

Pediatric cancer in Jordan accounts for 4-6% of all registered cases annually. While treatment is government-covered, limited palliative care necessitates developing new services.

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Area of Science:

  • Oncology
  • Pediatrics
  • Public Health

Background:

  • Pediatric cancer represents a significant health concern in Jordan, comprising 4-6% of all cancer cases.
  • Cancer incidence in children under 15 requires comprehensive data review for effective planning.

Purpose of the Study:

  • To review population-based data on pediatric oncology in Jordan.
  • To assess the current landscape of pediatric cancer care, including treatment and palliative services.

Main Methods:

  • Review of population-based cancer surveillance data.
  • Analysis of cancer types and treatment accessibility in Jordan.

Main Results:

  • Leukemia and central nervous system cancers are the most prevalent types in children.
  • Treatment is government-funded, accessible through major hospitals like King Hussein Cancer Center (KHCC).
  • Pediatric palliative care is currently limited to KHCC, highlighting a gap in comprehensive care.

Conclusions:

  • Jordan has established pediatric cancer treatment infrastructure with government support.
  • There is a critical need to expand pediatric palliative care services beyond KHCC and implement home care programs.