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Updated: Jun 5, 2026

Quantification of Colonic Stem Cell Mutations
Published on: September 25, 2015
Mediterranean glucose-6-phosphate dehydrogenase (G6PD(C563T)) mutation among Jordanian females with acute hemolytic
Abdullah Abdul Jabbar Ahmed Al-Alimi1, Naeem Kanakiri, Muhammad Kamil
1Department of Haematolgy, Advanced Medical and Dental Institute (AMDI), University Sains Malaysia, Malaysia.
Objective:
To evaluate the G6PD(C563T) Mediterranean mutation among Jordanian females who were admitted to Princess Rahma Teaching Hospital (PRTH) with/or previous history of favism.
Study Design:
A descriptive study.
Place And Duration Of Study:
Jordanian University of Science and Technology and PRTH, from October 2003 to October 2004.
Methodology:
After obtaining approval from the Ethics Committee of Jordanian University of Science and Technology, a total of 32 females were included in this study. Samples from 15 healthy individual females were used as a negative control. Blood samples from these patients were collected and analyzed by allele-specific polymerase chain reaction (AS-PCR) to determine the G6PD(C563T) mutation.
Results:
Twenty one out of 32 patients were found to be G6PD(C563T) Mediterranean mutation (65.6%) positive. Three out of 21 patients were homozygous and remaining 18 were heterozygous for G6PD(C563T) Mediterranean mutation. Eleven (34.4%) out of 32 patients were found to be negative for G6PD(C563T) mutation indicating the presence of other G6PD mutations in the study sample.
Conclusion:
G6PD(C563T) Mediterranean mutation accounted for 65.6% of the study sample with favism in the North of Jordan. There is likely to be another G6PD deficiency variant implicated in acute hemolytic crisis (favism).
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