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Related Experiment Video

Updated: May 24, 2026

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

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Published on: September 1, 2011

Hyperprolactinemia with aripiprazole: understanding the paradox.

Gayatri Saraf¹, Rishikesh V Behere, Ganesan Venkatasubramanian

¹1The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India; and 2Department of Psychiatry, Kasturba Medical College, Manipal University, Manipal, India.

American Journal of Therapeutics

|February 24, 2012

Summary

Aripiprazole, a dopamine D2 receptor partial agonist, can paradoxically cause hyperprolactinemia. This side effect may be dose-dependent, suggesting higher doses exhibit dopamine antagonistic properties affecting prolactin levels.

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Area of Science:

Neuropharmacology
Endocrinology

Background:

Aripiprazole is frequently chosen for antipsychotic-induced hyperprolactinemia due to its partial D2 receptor agonism.
Hyperprolactinemia is a common side effect of antipsychotic medications, impacting dopamine pathways.

Observation:

A case study details a female patient developing hyperprolactinemia during aripiprazole treatment.
This observation challenges the typical use of aripiprazole in managing this condition.

Findings:

Aripiprazole's partial D2 agonistic activity may be dose-dependent.
At higher dosages, aripiprazole might exert dopamine antagonistic effects, leading to prolactin system abnormalities.

Implications:

The findings suggest a need to monitor prolactin levels in patients on higher doses of aripiprazole.
This highlights potential complexities in managing hyperprolactinemia with atypical antipsychotics.
Further research into dose-related effects of aripiprazole on prolactin is warranted.