[Effect of pyrazinoic acid on the transport function of the peritoneum--experimental studies]

Bidirectional transport of the urea, uric acid and albumin across parietal peritoneum was investigated in vitro under both normal conditions and following an administration of pyrazinoic acid. It was found that pyrazinoic acid decreased urea and uric acid transport from interstitial to mesothelial surface of the peritoneal membrane but did not affect the transport in reverse direction. Bidirectional transport of albumin remained unchanged. The obtained results are similar to those reported earlier and suggest that pyrazinamide actions are partially selective.