[Topographic differentiation of transperitoneal glucose transport: in vitro studies]

The dynamics of bidirectional glucose transport across parietal peritoneum from anterior abdominal wall or diaphragm and small-bowel mesentery was analyzed. The mean transport values, expressed as transport coefficients, of intact peritoneum amounted 2.61; 0.18; 5.43 (10(-4) x cm x S-1), respectively. The chemical destruction of the mesothelium (2.5 mmol/l sodium deoxycholate) increased transperitoneal glucose transport across the investigated tissues. However, the intensification of transfer was different. Removal of the diaphragm pleural mesothelium caused greater increase of bidirectional glucose transport than the peritoneal mesothelium. Furthermore, the mean values of transport coefficient after peritoneal mesothelium damage were higher in relation to mesentery than to the peritoneum isolated from anterior abdominal wall and diaphragm. The obtained results suggest topographic heterogeneity of peritoneal membrane which refer to the mesothelium and submesothelial layers.